You should always read the motherboard / system manufacturer’s information to confirm which lengths are supported, but many motherboards will support 2260, 2280 and 22110. Many motherboards will provide multiple retaining-screw offset, allowing a user to secure either a 2242, 2260, 2280, or even up to 22100 M.2 SSD. The amount of space on the motherboard will limit the size of M.2 SSDs that can be secured into the socket and used.